{"id":1392,"date":"2026-02-23T14:43:39","date_gmt":"2026-02-23T12:43:39","guid":{"rendered":"https:\/\/kildosklinika.lt\/?p=1392"},"modified":"2026-02-23T14:43:39","modified_gmt":"2026-02-23T12:43:39","slug":"neinvazinis-prenatalinis-tyrimas-nipt","status":"publish","type":"post","link":"https:\/\/kildosklinika.lt\/en\/straipsniai\/neinvazinis-prenatalinis-tyrimas-nipt\/","title":{"rendered":"Neinvazinis n\u0117\u0161tumo apsigimim\u0173 ir lyties genetinis tyrimas NIPT"},"content":{"rendered":"<p><span style=\"color: #000000;\">NIPT (neinvazin\u0117 prenatalin\u0117 patikra) \u2013 novatori\u0161kas, neinvazinis, saugus ir patikimas i\u0161tyrimas d\u0117l vaisiaus b\u016bkl\u0117s ir chromosomini\u0173 anomalij\u0173\u00a0 &gt; 97 \u2013 99,9 % tikslumu bei vaisiaus lyties nustatymas jau nuo 9 &#8211; 10 n\u0117\u0161tumo savait\u0117s (priklauso nuo pasirinkto NIPT varianto).<\/span><\/p>\n<p><span style=\"color: #000000;\">Tyrimas atliekamas i\u0161 \u012fprastinio n\u0117\u0161\u010diosios kraujo m\u0117ginio jau nuo 9 &#8211; 10 n\u0117\u0161tumo savai\u010di\u0173. I\u0161sami vaisiaus DNR analiz\u0117 atliekama moderniose laboratorijose Ispanijoje, Kipre ar Vokietijoje.<\/span><\/p>\n<p><span style=\"color: #000000;\">Si\u016blomi modern\u016bs pa\u017eang\u016bs ir profesional\u016bs tyrimai labai tiksliai ir patikimai gali suteikti papildomos informacijos apie galim\u0105 patologij\u0105, kad b\u016bt\u0173 laiku atlikti invaziniai prenataliniai genetiniai tyrimai, kurie patvirtint\u0173 ar paneigt\u0173 patologinius NIPT rezultatus.<\/span><\/p>\n<h5><span style=\"color: #000000;\"><strong>K\u0105 gali nustatyti NIPT?<\/strong><\/span><\/h5>\n<p><span style=\"color: #000000;\">Priklausomai nuo pasirinkto atlikti NIPT varianto, tiriama:<\/span><\/p>\n<ul>\n<li><span style=\"color: #000000;\">Da\u017eniausios trisomijos <strong>: <\/strong>Dauno (T21), Edvardo (T18) ir Patau (T13) sindromai.<\/span><\/li>\n<li><span style=\"color: #000000;\">Lytini\u0173 chromosom\u0173 anomalijos: X ir Y chromosom\u0173 skai\u010diaus pakitimai.<\/span><\/li>\n<li><span style=\"color: #000000;\">Vaisiaus lytis.<\/span><\/li>\n<li><span style=\"color: #000000;\">Vis\u0173 kit\u0173 autosom\u0173 aneuploidijos: Retos vis\u0173 likusi\u0173 chromosom\u0173 (1\u201322) skai\u010diaus anomalijos.<\/span><\/li>\n<\/ul>\n<h5><span style=\"color: #000000;\"><strong>Kokias trisomijas nustato NIPT ?<\/strong><\/span><\/h5>\n<ul>\n<li><span style=\"color: #000000;\">21 trisomija (Dauno sindromas): labiausiai paplitusi trisomija. Klinikiniai po\u017eymiai apima b\u016bdingus veido bruo\u017eus, \u012fvairaus laipsnio intelektin\u0119 negali\u0105, \u0161irdies ydas ir raidos atsilikim\u0105. \u0160i liga pasirei\u0161kia v\u0117luojan\u010di\u0173 pa\u017einimo geb\u0117jim\u0173 vystymusi \u2013 protiniu atsilikimu bei sutrikusiu arba v\u0117luojan\u010diu fiziniu augimu.<\/span><\/li>\n<li><span style=\"color: #000000;\">18 trisomija (Edvardso sindromas): sunkus genetinis sutrikimas, pasirei\u0161kiantis augimo atsilikimu, specifin\u0117mis rank\u0173 bei p\u0117d\u0173 deformacijomis, sunkiomis vidaus organ\u0173 (\u0161irdies, inkst\u0173) ydomis. \u0160is sindromas da\u017enai yra nesuderinamas su ilgu gyvenimu, o da\u017enai vaisius \u017e\u016bsta iki gimimo.<\/span><\/li>\n<li><span style=\"color: #000000;\">13 trisomija (Patau sindromas): sukelia itin sunkius sklaidos defektus, tokius kaip l\u016bpos\/gomurio skeltumas, ma\u017eos akys (mikroftalmija), galvos smegen\u0173 bei \u0161irdies ydos. Da\u017enai vaisius \u017e\u016bsta iki gimimo, o jei gimsta, i\u0161gyvenamumas labai trumpas.<\/span><\/li>\n<\/ul>\n<h5><span style=\"color: #000000;\"><strong>Kokios galimos vaisiaus lyties aneuploidijos ir sindromai?<\/strong><\/span><\/h5>\n<p><span style=\"color: #000000;\">Lyties chromosom\u0173 aneuploidijos (nenormalus lytini\u0173 chromosom\u0173 skai\u010dius) pasi\u017eymi tuo, kad jos da\u017enai nekelia rimt\u0173 sveikatos sutrikim\u0173, ta\u010diau sukelia specifini\u0173 endokrinini\u0173, reprodukcini\u0173 ir raidos sutrikim\u0173. \u017dinomiausios:<\/span><\/p>\n<ul>\n<li><span style=\"color: #000000;\">Ternerio sindromas (45, X): Moterims tr\u016bksta vienos X chromosomos (monosomija). B\u016bdingas ma\u017eas \u016bgis, lytini\u0173 liauk\u0173 disfunkcija, galimos \u0161irdies ydos.<\/span><\/li>\n<li><span style=\"color: #000000;\">Klainfelterio sindromas (47, XXY): Vyrams b\u016bdinga papildoma X chromosoma. Tai gali lemti ma\u017eesn\u0119 s\u0117klid\u017ei\u0173 funkcij\u0105, nevaisingum\u0105, fizinius poky\u010dius.<\/span><\/li>\n<li><span style=\"color: #000000;\">Trigubos X sindromas (47, XXX): Moterims b\u016bdinga papildoma X chromosoma, da\u017enai pasirei\u0161kianti be ai\u0161ki\u0173 simptom\u0173, kartais \u2013 mokymosi sutrikimais, v\u0117luojan\u010dia raida, prie\u0161laikiniu kiau\u0161id\u017ei\u0173 funkcijos i\u0161sekimu.<\/span><\/li>\n<li><span style=\"color: #000000;\">XYY (Jacobso) sindromas (47, XYY): Vyrams b\u016bdinga papildoma Y chromosoma, da\u017eniausiai nesukelianti dideli\u0173 sveikatos problem\u0173, bet gali kelti fizini\u0173, emocini\u0173, elgesio sutrikimo, galimas \u017eemesnis IQ, mokymosi sunkumai, tiriamos s\u0105sajos su autizmu.<\/span><\/li>\n<\/ul>\n<h5><span style=\"color: #000000;\"><strong>Kurios mikrodelecijos da\u017eniausiai nustatomos ir kuo jos svarbios?<\/strong><\/span><\/h5>\n<ul>\n<li><span style=\"color: #000000;\">1p36 delecija<\/span><\/li>\n<li><span style=\"color: #000000;\">Wolf- Hirschorn sindromas<\/span><\/li>\n<li><span style=\"color: #000000;\">Smith-Magenis sindromas<\/span><\/li>\n<li><span style=\"color: #000000;\">Angelman sindromas<\/span><\/li>\n<li><span style=\"color: #000000;\">Prader-Willi sindromas<\/span><\/li>\n<li><span style=\"color: #000000;\">Cri-du-chat sindromas<\/span><\/li>\n<\/ul>\n<p><span style=\"color: #000000;\">Mikrodeleciniai sindromai (Angelmano, Prader-Willio, \u201eKat\u0117s kniaukimo\u201c, 22q11.2 (Di D\u017eord\u017eo) bei 1p36 delecijos) pasitaiko da\u017eniau nei prie\u0161 tai manyta. \u0160ie 5 da\u017eniausia mikrodeleciniai sindromai aptinkami 1 i\u0161 1000 n\u0117\u0161\u010di\u0173j\u0173. Mikrodeleciniai sindromai pasirei\u0161kia raidos ir augimo atsilikimu, kai kuriais atvejais galimi poky\u010diai vidaus organuose.<\/span><\/p>\n<h5><span style=\"color: #000000;\"><strong>Kas yra monogenin\u0117s ligos?<\/strong><\/span><\/h5>\n<p><span style=\"color: #000000;\">\u0160ios ligos gali b\u016bti perduodamos i\u0161 t\u0117v\u0173 vaikams arba atsirasti d\u0117l nauj\u0173 mutacij\u0173 (de novo).Kokia tikimyb\u0117 paveld\u0117ti lig\u0105 ir ja susirgti-priklauso nuo ligos ir jos tipo. \u0160ios paveldimos ligos\u00a0 skirstomos \u012f pagrindinius tipus:<\/span><\/p>\n<ul>\n<li><span style=\"color: #000000;\">Autosomin\u0117s dominantin\u0117s: ligos pasirei\u0161kimui u\u017etenka vienos pakitusio geno kopijos (pvz., Hantingtono liga arba Marfano sindromas).<\/span><\/li>\n<li><span style=\"color: #000000;\">Autosomin\u0117s recesyvin\u0117s: liga pasirei\u0161kia tik tada, kai abi geno kopijos yra pa\u017eeistos. Jei \u017emogus turi tik vien\u0105 pa\u017eeist\u0105 kopij\u0105, jis yra sveikas ligos ne\u0161iotojas (pvz., cistin\u0117 fibroz\u0117, fenilketonurija).<\/span><\/li>\n<li><span style=\"color: #000000;\">Su lytimi (X chromosoma) sukibusios: genas yra lytin\u0117je X chromosomoje,- moterys ne\u0161iotojos, o liga da\u017eniau pasirei\u0161kia vyrams (pvz., hemofilija).<\/span><\/li>\n<\/ul>\n<p><span style=\"color: #000000;\">Tyrimui atlikti reikalingas motinos kraujas ir biologinio t\u0117vo skruosto gleivin\u0117s m\u0117ginys (VERAgene NIPT).<\/span><\/p>\n<h5><span style=\"color: #000000;\"><strong>Galima rinktis i\u0161 \u0161i\u0173 NIPT si\u016blom\u0173 variant\u0173:<\/strong><\/span><\/h5>\n<p><span style=\"color: #000000;\"><span style=\"text-decoration: underline;\">NeoBona Basic NIPT<\/span> 13,18,21 trisomijos, su lyties nustatymu &#8211; 450 eur.<\/span><\/p>\n<p><span style=\"color: #000000;\"><span style=\"text-decoration: underline;\">NeoBona Advanced NIPT<\/span> 13,18,21\u00a0 trisomijos, lytini\u0173 chromosom\u0173 skai\u010diaus aneuploidijos, mikrodelecijos,\u00a0 su lyties nustatymu &#8211; 520 eur.<\/span><\/p>\n<p><span style=\"color: #000000;\"><span style=\"text-decoration: underline;\">NeoBona GenomeWide NIPT<\/span>\u00a0 13,18,21\u00a0 trisomijos, lytini\u0173 chromosom\u0173 skai\u010diaus aneuploidijos, mikrodelecijos, vis\u0173 chromosom\u0173 por\u0173 aneuploidij\u0173 analiz\u0117,\u00a0 su lyties nustatymu &#8211; 620 eur.<\/span><\/p>\n<p><span style=\"color: #000000;\"><span style=\"text-decoration: underline;\">VERACITY NIPT<\/span> 13,18,21 aneuplodijos X,Y, su lyties nustatymu &#8211; 450 eur.<\/span><\/p>\n<p><span style=\"color: #000000;\"><span style=\"text-decoration: underline;\">VERACITY NIPT<\/span> 13,18, 21 aneuplodijos X.Y su lyties nustatymu ir <span style=\"text-decoration: underline;\">mikrodelecij\u0173 tyrimu<\/span> &#8211; 550 eur.<\/span><\/p>\n<p><span style=\"color: #000000;\"><span style=\"text-decoration: underline;\">VERAgene NIPT<\/span> 13,18, 21 aneuplodijos X.Y su lyties nustatymu ir mikrodelecij\u0173 tyrimu ir <span style=\"text-decoration: underline;\">100 monogenini\u0173 lig\u0173<\/span>\u00a0 (<strong>Monogenin\u0117s ligos:<\/strong> nustato autosominius dominantinius ir recesyvinius susirgimus (pvz., cistin\u0119 fibroz\u0119, \u012fgimt\u0105 antinks\u010di\u0173 hiperplazij\u0105)- 690 eur.<\/span><\/p>\n<h5><span style=\"color: #000000;\"><strong>Rezultatai\u00a0<\/strong><\/span><\/h5>\n<p><span style=\"color: #000000;\">Rezultatai pateikiami per 5-7 d.d. arba 8 &#8211; 10 d.d. priklausomai kur\u012f NIPT variant\u0105 renkasi n\u0117\u0161\u010dioji.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #000000;\">D\u0117l tyrimo atlikimo kreipkit\u0117s konsultacijai pas gydytoj\u0105 aku\u0161er\u0119 ginekolog\u0119. Registruotis konsultacijai galima telefonu +370 37 338 286 arba <a style=\"color: #000000;\" href=\"https:\/\/kreg.medsystem.lt\/Login.aspx?SK_ID=15\">internetu<\/a>.<\/span><\/p>\n<pre><em><span style=\"color: #000000;\">Informacij\u0105 straipsniui pareng\u0117 UAB \u2018\u2018VAKK\u2018\u2018 Dr. A. Kildos klinikos <a style=\"color: #000000;\" href=\"https:\/\/kildosklinika.lt\/en\/gydytojai\/ingrida-jackuniene\/\">gyd. aku\u0161er\u0117 \u2013 ginekolog\u0117 Ingrida Jack\u016bnien\u0117<\/a><\/span><\/em><\/pre>","protected":false},"excerpt":{"rendered":"<p>NIPT (neinvazin\u0117 prenatalin\u0117 patikra) \u2013 novatori\u0161kas, neinvazinis, saugus ir patikimas i\u0161tyrimas d\u0117l vaisiaus b\u016bkl\u0117s ir chromosomini\u0173 anomalij\u0173\u00a0 &gt; 97 \u2013 99,9 % tikslumu bei vaisiaus lyties nustatymas jau nuo<\/p>","protected":false},"author":3,"featured_media":1406,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[128],"tags":[],"service":[47],"specializacijos":[11],"class_list":["post-1392","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-skyrelis-moterims","service-genetiniai-tyrimai","specializacijos-akuseriai-ginekologai"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - 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